SAKAI Hideki

写真a

Title

Professor

Research Fields, Keywords

Cell Physiology, Electrophysiology, Biophysical Chemistry

Graduating School 【 display / non-display

  • 1981.04
    -
    1985.03

    Toyama Medical and Pharmaceutical University   Faculty of Pharmaceutical Science   Graduated

Graduate School 【 display / non-display

  • 1987.04
    -
    1992.03

    Toyama Medical and Pharmaceutical University  Graduate School, Division of Pharmaceutical Sciences  Doctor's Course  Completed

  • 1985.04
    -
    1987.03

    Toyama Medical and Pharmaceutical University  Graduate School, Division of Pharmaceutical Sciences  Master's Course  Completed

Campus Career 【 display / non-display

  • 2019.10
     
     

    University of ToyamaAcademic Assembly   Faculty of Pharmaceutical Sciences   Professor  

  • 2019.10
     
     

    University of ToyamaFaculty of Pharmacy and Pharmaceutical Sciences   Department of Pharmacy   Professor  

  • 2018.04
     
     

    University of ToyamaFaculty of Pharmacy and Pharmaceutical Sciences   Manager(Dean)  

  • 2018.04
     
     

    University of ToyamaGraduate School of Medicine and Pharmaceutical Sciences for Research   Manager(Dean)  

  • 2006.04
    -
    2019.09

    University of ToyamaGraduate School of Medicine and Pharmaceutical Sciences for Research   Advanced Biomedicine   Genome Pharmaceutical Science   Professor  

display all >>

Academic Society Affiliations 【 display / non-display

  • 2002.04
     
     
     

    The Physiological Society

Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • General physiology

  • Biological pharmacy

 

Research project summary 【 display / non-display

  • We study about ion-transporting proteins in epithelial cells by using physiological, biochemical and pharmacological techniques.

Papers 【 display / non-display

  • Crosstalk between Na+,K+-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells.

    3) Fujii T, Shimizu T, Yamamoto S, Funayama K, Fujita K, Tabuchi Y, Ikari A, Takeshima H, Sakai H

    Biochim Biophys Acta Mol Basis Dis   1864 ( 11 ) 3792 - 3804   2018.11

    Joint Work

  • The natural flavonoid myricetin inhibits gastric H+, K+-ATPase.

    Miyazaki Y, Ichimura A, Sato S, Fujii T, Oishi S, Sakai H, Takeshima H

    Eur J Pharmacol   820   217 - 221   2018.02

    Joint Work

  • Inhibition of gastric H+,K+-ATPase activity in vitro by dissolution media of original brand-name and generic tablets of Lansoprazole, a proton pump inhibitor.

    Phutthatiraphap S, Hayashi Y, Fujii T, Kosugi A, Okada K, Kadozaki T, Ishise T, Sakai H, Onuki Y

    Chem Pharm Bull   66 ( 9 ) 896 - 900   2018

    Joint Work

  • Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models.

    Maruhashi R, Akizuki R, Sato T, Matsunaga T, Endo S, Yamaguchi M, Yamazaki Y, Sakai H, Ikari A

    Biochim Biophys Acta   1865 ( 3 ) 470 - 479   2017.12

    Joint Work

  • The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation.

    Shimizu T, Higuchi T, Toba T, Ohno C, Fujii T, Nilius B, Sakai H

    FEBS Open Bio   7 ( 9 ) 1392 - 1401   2017.08

    Joint Work

display all >>

Books 【 display / non-display

  • Met Ions Life Sci., Proton-potassium (H+/K+) ATPases: Properties and roles in health and diseases.

    Sakai H, Fujii T, Takeguchi N. (Part: Joint Work )

    Springer  2016

Review Papers 【 display / non-display

  • An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solution.

    Hibino H, Takai M, Noguchi H, Sawamura S, Takahashi Y, Sakai H, Shiku H

    J Physiol Sci   67 ( 4 ) 439 - 445   2017.07

    Introduction and explanation (bulletin of university, research institution)   Joint Work

  • Function of K+-Cl- cotransporters in the acid secretory mechanism of gastric parietal cells.

    Fujii T, Fujita K, Takeguchi N, Sakai H.

    Biol. Pharm. Bull. ( The Pharmaceutical Society of Japan )  34 ( 6 ) 810 - 812   2011.06

    Introduction and explanation (scientific journal)   Joint Work

Grant-in-Aid for Scientific Research 【 display / non-display

  • Grant-in-Aid for challenging Exploratory Research

    Project Year: 2016.04  -  2018.03 

  • Grant-in-Aid for challenging Exploratory Research

    Project Year: 2015.04  -  2017.03 

  • Grant-in-Aid for Scientific Research(B)

    Project Year: 2013.04  -  2016.03 

  • Grant-in-Aid for Exploratory Research

    Project Year: 2012.04  -  2014.03